Antikolinergien käyttö virtsankarkailun hoidossa gerasteenisilla, monisairailla ja muistihäiriöisillä iäkkäillä

Lisätietoa aiheesta
Maria Nuotio

Käytännön ohjeita



Haittavaikutusten mekanismi ja lääkkeiden yhteisvaikutuksia


  1. Kraus SR, Bavendam T, Brake T ym. Vulnerable elderly patients and overactive bladder syndrome. Drugs Aging 2010;27:697-713 «PMID: 20809661»PubMed
  2. Kalder M, Pantazis K, Dinas K ym. Discontinuation of treatment using anticholinergic medications in patients with urinary incontinence. Obstet Gynecol 2014;124:794-800 «PMID: 25198276»PubMed
  3. Wagg A, Arumi D, Herschorn S ym. A pooled analysis of the efficacy of fesoterodine for the treatment of overactive bladder, and the relationship between safety, co-morbidity and polypharmacy in patients aged 65 years or older. Age Ageing 2017 «PMID: 28057620»PubMed
  4. Kay GG, Granville LJ. Antimuscarinic agents: implications and concerns in the management of overactive bladder in the elderly. Clin Ther 2005;27:127-38; quiz 139-40 «PMID: 15763613»PubMed
  5. Kraus SR, Bavendam T, Brake T ym. Vulnerable elderly patients and overactive bladder syndrome. Drugs Aging 2010;27:697-713 «PMID: 20809661»PubMed
  6. Kay GG, Abou-Donia MB, Messer WS Jr ym. Antimuscarinic drugs for overactive bladder and their potential effects on cognitive function in older patients. J Am Geriatr Soc 2005;53:2195-201 «PMID: 16398909»PubMed
  7. Popescu BO, Toescu EC, Popescu LM ym. Blood-brain barrier alterations in ageing and dementia. J Neurol Sci 2009;283:99-106 «PMID: 19264328»PubMed
  8. Paquette A, Gou P, Tannenbaum C. Systematic review and meta-analysis: do clinical trials testing antimuscarinic agents for overactive bladder adequately measure central nervous system adverse events? J Am Geriatr Soc 2011;59:1332-9 «PMID: 21718264»PubMed
  9. Wagg A, Khullar V, Marschall-Kehrel D ym. Flexible-dose fesoterodine in elderly adults with overactive bladder: results of the randomized, double-blind, placebo-controlled study of fesoterodine in an aging population trial. J Am Geriatr Soc 2013;61:185-93 «PMID: 23350833»PubMed
  10. Dubeau CE, Kraus SR, Griebling TL ym. Effect of fesoterodine in vulnerable elderly subjects with urgency incontinence: a double-blind, placebo controlled trial. J Urol 2014;191:395-404 «PMID: 23973522»PubMed
  11. Gill SS, Mamdani M, Naglie G ym. A prescribing cascade involving cholinesterase inhibitors and anticholinergic drugs. Arch Intern Med 2005;165:808-13 «PMID: 15824303»PubMed
  12. Sink KM, Thomas J 3rd, Xu H ym. Dual use of bladder anticholinergics and cholinesterase inhibitors: long-term functional and cognitive outcomes. J Am Geriatr Soc 2008;56:847-53 «PMID: 18384584»PubMed
  13. Isik AT, Celik T, Bozoglu E ym. Trospium and cognition in patients with late onset Alzheimer disease. J Nutr Health Aging 2009;13:672-6 «PMID: 19657549»PubMed
  14. Hashimoto M, Imamura T, Tanimukai S ym. Urinary incontinence: an unrecognised adverse effect with donepezil. Lancet 2000;356:568 «PMID: 10950240»PubMed
  15. Carrière I, Fourrier-Reglat A, Dartigues JF ym. Drugs with anticholinergic properties, cognitive decline, and dementia in an elderly general population: the 3-city study. Arch Intern Med 2009;169:1317-24 «PMID: 19636034»PubMed
  16. Lampela P, Taipale H, Hartikainen S. Use of Cholinesterase Inhibitors Increases Initiation of Urinary Anticholinergics in Persons with Alzheimer's Disease. J Am Geriatr Soc 2016;64:1510-2 «PMID: 27401848»PubMed
  17. Jessen F, Kaduszkiewicz H, Daerr M ym. Anticholinergic drug use and risk for dementia: target for dementia prevention. Eur Arch Psychiatry Clin Neurosci 2010;260 Suppl 2:S111-5 «PMID: 20960005»PubMed
  18. Gray SL, Anderson ML, Dublin S ym. Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study. JAMA Intern Med 2015;175:401-7 «PMID: 25621434»PubMed
  19. Boudreau DM, Yu O, Gray SL ym. Concomitant use of cholinesterase inhibitors and anticholinergics: prevalence and outcomes. J Am Geriatr Soc 2011;59:2069-76 «PMID: 22091958»PubMed
  20. Samuelsson E, Odeberg J, Stenzelius K ym. Effect of pharmacological treatment for urinary incontinence in the elderly and frail elderly: A systematic review. Geriatr Gerontol Int 2015;15:521-34 «PMID: 25656412»PubMed
Käypä hoito -suositukset ovat riippumattomia, tutkimusnäyttöön perustuvia kansallisia hoitosuosituksia. Lue lisää
KÄYPÄ HOITO -SUOSITUS Virtsankarkailu (naiset)
Linkki toiselle sivustolle