Masennuslääkkeistä ainakin SSRI -lääkkeet ja venlafaksiini ovat tehokkaita yksittäisten
ahdistuneisuushäiriöiden hoidossa.
Lukuisissa lumekontrolloiduissa tutkimuksissa on osoitettu SSRI-lääkkeiden (selektiivinen
serotoniinin takaisinoton estäjä) teho eri ahdistuneisuushäiriöissä, kuten sosiaalisessa
fobiassa «Baldwin D, Bobes J, Stein DJ ym. Paroxetine in soc...»1, «Katzelnick DJ, Kobak KA, Greist JH ym. Sertraline ...»2, «Schneier FR, Goetz D, Campeas R ym. Placebo-contro...»3, «Stein MB, Liebowitz MR, Lydiard RB ym. Paroxetine ...»4, «Stein MB, Fyer AJ, Davidson JR ym. Fluvoxamine tre...»5, paniikkihäiriössä «Pollack MH, Rapaport MH, Clary CM ym. Sertraline t...»6, «Boyer W. Serotonin uptake inhibitors are superior ...»7, «Clum GA, Clum GA, Surls R. A meta-analysis of trea...»8, «Lepola UM, Wade AG, Leinonen EV ym. A controlled, ...»9, «Loerch B, Graf-Morgenstern M, Hautzinger M ym. Ran...»11, «Londborg PD, Wolkow R, Smith WT ym. Sertraline in ...»12, «Michelson D, Lydiard RB, Pollack MH ym. Outcome as...»13 , «Oehrberg S, Christiansen PE, Behnke K ym. Paroxeti...»14, «Wade AG, Lepola U, Koponen HJ ym. The effect of ci...»15, «Michelson D, Allgulander C, Dantendorfer K ym. Eff...»18 ja yleistyneessä ahdistuneisuushäiriössä (GAD) «Allgulander C, Hackett D, Salinas E. Venlafaxine e...»10, «Rickels K, Downing R, Schweizer E ym. Antidepressa...»16, «Rickels K, Pollack MH, Sheehan DV ym. Efficacy of ...»17.
- Tutkimuksen laatu: tasokas
- Sovellettavuus suomalaiseen väestöön: kohtalainen
Perusterveydenhuollon ja psykiatrisen avohoidon potilailla tehdyssä, 541 potilaan
24 viikon lumekontrolloidussa tutkimuksessa «Allgulander C, Hackett D, Salinas E. Venlafaxine e...»10 venlafaksiini oli tehokas yleistyneen ahdistuneisuushäiriön oireisiin. Hitaasti liukeneva
venlafaksiini annoksella 150 mg/vrk vähensi Hamiltonin ahdistuneisuusasteikolla (HRSA
total) mitattuna ahdistuneisuutta 24 viikon seurannassa lumetta merkittävästi enemmän
(-16,4 vs -11,0, p < 0,017).
- Tutkimuksen laatu: tasokas
- Sovellettavuus suomalaiseen väestöön: hyvä
Kirjallisuutta
- Baldwin D, Bobes J, Stein DJ ym. Paroxetine in social phobia/social anxiety disorder.
Randomised, double-blind, placebo-controlled study. Paroxetine Study Group. Br J Psychiatry
1999;175:120-6 «PMID: 10627793»PubMed
- Katzelnick DJ, Kobak KA, Greist JH ym. Sertraline for social phobia: a double-blind,
placebo-controlled crossover study. Am J Psychiatry 1995;152:1368-71 «PMID: 7653696»PubMed
- Schneier FR, Goetz D, Campeas R ym. Placebo-controlled trial of moclobemide in social
phobia. Br J Psychiatry 1998;172:70-7 «PMID: 9534836»PubMed
- Stein MB, Liebowitz MR, Lydiard RB ym. Paroxetine treatment of generalized social
phobia (social anxiety disorder): a randomized controlled trial. JAMA 1998;280:708-13
«PMID: 9728642»PubMed
- Stein MB, Fyer AJ, Davidson JR ym. Fluvoxamine treatment of social phobia (social
anxiety disorder): a double-blind, placebo-controlled study. Am J Psychiatry 1999;156:756-60
«PMID: 10327910»PubMed
- Pollack MH, Rapaport MH, Clary CM ym. Sertraline treatment of panic disorder: response
in patients at risk for poor outcome. J Clin Psychiatry 2000;61:922-7 «PMID: 11206597»PubMed
- Boyer W. Serotonin uptake inhibitors are superior to imipramine and alprazolam in
alleviating panic attacks: a meta-analysis. Int Clin Psychopharmacol 1995;10:45-9
«PMID: 7622804»PubMed
- Clum GA, Clum GA, Surls R. A meta-analysis of treatments for panic disorder. J Consult
Clin Psychol 1993;61:317-26 «PMID: 8097212»PubMed
- Lepola UM, Wade AG, Leinonen EV ym. A controlled, prospective, 1-year trial of citalopram
in the treatment of panic disorder. J Clin Psychiatry 1998;59:528-34 «PMID: 9818634»PubMed
- Allgulander C, Hackett D, Salinas E. Venlafaxine extended release (ER) in the treatment
of generalised anxiety disorder: twenty-four-week placebo-controlled dose-ranging
study. Br J Psychiatry 2001;179:15-22 «PMID: 11435263»PubMed
- Loerch B, Graf-Morgenstern M, Hautzinger M ym. Randomised placebo-controlled trial
of moclobemide, cognitive-behavioural therapy and their combination in panic disorder
with agoraphobia. Br J Psychiatry 1999;174:205-12 «PMID: 10448444»PubMed
- Londborg PD, Wolkow R, Smith WT ym. Sertraline in the treatment of panic disorder.
A multi-site, double-blind, placebo-controlled, fixed-dose investigation. Br J Psychiatry
1998;173:54-60 «PMID: 9850204»PubMed
- Michelson D, Lydiard RB, Pollack MH ym. Outcome assessment and clinical improvement
in panic disorder: evidence from a randomized controlled trial of fluoxetine and placebo.
The Fluoxetine Panic Disorder Study Group. Am J Psychiatry 1998;155:1570-7 «PMID: 9812120»PubMed
- Oehrberg S, Christiansen PE, Behnke K ym. Paroxetine in the treatment of panic disorder.
A randomised, double-blind, placebo-controlled study. Br J Psychiatry 1995;167:374-9
«PMID: 7496647»PubMed
- Wade AG, Lepola U, Koponen HJ ym. The effect of citalopram in panic disorder. Br J
Psychiatry 1997;170:549-53 «PMID: 9330022»PubMed
- Rickels K, Downing R, Schweizer E ym. Antidepressants for the treatment of generalized
anxiety disorder. A placebo-controlled comparison of imipramine, trazodone, and diazepam.
Arch Gen Psychiatry 1993;50:884-95 «PMID: 8215814»PubMed
- Rickels K, Pollack MH, Sheehan DV ym. Efficacy of extended-release venlafaxine in
nondepressed outpatients with generalized anxiety disorder. Am J Psychiatry 2000;157:968-74
«PMID: 10831478»PubMed
- Michelson D, Allgulander C, Dantendorfer K ym. Efficacy of usual antidepressant dosing
regimens of fluoxetine in panic disorder: randomised, placebo-controlled trial. Br
J Psychiatry 2001;179:514-8 «PMID: 11731354»PubMed